Stop Leaving 340B Revenue on the Table

Many covered entities underestimate how much revenue they lose from missed 340B claims. The truth is, these dollars add up quickly. In 2025, with drug costs continuing to rise and manufacturers tightening contract pharmacy restrictions, every missed claim can mean significant lost savings for hospitals, FQHCs, and health systems.

The Real Cost of Missed Claims

Research shows that missed 340B claims can cost covered entities millions of dollars annually. According to the American Hospital Association, hospitals already spend over $115 billion a year on prescription drugs, making every eligible 340B claim critical. Studies from the Government Accountability Office (GAO) and HRSA indicate that gaps in claim capture are a leading cause of reduced program benefit.

Common sources of lost claims include:

  • Errors in TPA eligibility matching.

  • Lack of real-time data synchronization between EMRs and TPAs.

  • Complexities in managing multiple contract pharmacy relationships.

  • Insufficient compliance oversight or outdated policies.

Why TPAs Miss Claims
Third-Party Administrators (TPAs) play a critical role in the 340B program but often lack transparency. According to 340B Health, TPAs are prone to errors due to:

  • Delayed data feeds from EMRs.

  • Inconsistent application of eligibility rules.

  • Limited visibility into contract pharmacy-level claim details.

  • Minimal audit readiness support for covered entities.

These limitations leave providers vulnerable to both compliance risks and revenue loss.

Halo340B’s Second Check Advantage

Halo340B was built to address these gaps. With its proprietary Second Check Engine, covered entities can:

  • Identify and recover up to 20% more eligible claims.

  • Independently validate TPA claim determinations.

  • Access real-time dashboards that show missed revenue potential.

  • Strengthen compliance oversight while maximizing program savings.

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HRSA Audit Readiness: A Proven Checklist for 340B Success

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The 340B Program in 2025: What Covered Entities Need to Know